Application | Comment | Organism |
---|---|---|
medicine | ATP8B1 deficiency leads to reduced PS flipping and impaired farnesoid X receptor signaling via impaired PKCgamma-mediated nuclear translocation of farnesoid X receptor, resulting in reduced bile salt export pump and enhanced apical sodium-dependent bile salt transporter activation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in UPS-1 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G308V | Atp8b1 protein is virtually undetectable in G308V mouse liver, the G308V substitution results in an instable protein that cannot exit the endoplasmic reticulum and is broken down by the proteasome | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q148W0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low distribution in brain | Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
pancreas | high distribution in pancreas | Mus musculus | - |
small intestine | high distribution in small intestine | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphatidylserine/out | - |
Mus musculus | ADP + phosphate + phosphatidylserine/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP8B1 | - |
Mus musculus |