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Literature summary for 7.6.2.1 extracted from

  • Liu, K.; Surendhran, K.; Nothwehr, S.F.; Graham, T.R.
    P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes (2008), Mol. Biol. Cell, 19, 3525-3535.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.1

Protein Variants

Protein Variants Comment Organism
additional information a conditional allele that inactivates Drs2p phospholipid translocase activity disrupts its own transport in this AP-1 pathway, missorting of Drs2p to the plasma membrane of AP-1 mutants, cell surface accumulation of GFP-Drs2p is less pronounced in apm1DELTA and nearly absent in apm2DELTA cells treated with latrunculin A, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface AP-1 is required, and GGA proteins, Golgi localized, gamma-ear containing, Arf-binding proteins acting as chlatrin adaptos, are dispensable, for efficient exclusion of Drs2p from exocytic vesicles targeted to the plasma membrane Saccharomyces cerevisiae 9986
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endosome loss of AP-1 markedly increases Drs2p trafficking to the plasma membrane, but does not perturb retrieval of Drs2p from the early endosome back to the trans Golgi network, AP-1 is required at the trans Golgi network to sort Drs2p out of the exocytic pathway, presumably for delivery to the early endosome Saccharomyces cerevisiae 5768
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Golgi apparatus loss of AP-1 markedly increases Drs2p trafficking to the plasma membrane, but does not perturb retrieval of Drs2p from the early endosome back to the trans Golgi network, AP-1 is required at the trans Golgi network to sort Drs2p out of the exocytic pathway, presumably for delivery to the early endosome Saccharomyces cerevisiae 5794
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plasma membrane loss of AP-1 markedly increases Drs2p trafficking to the plasma membrane, but does not perturb retrieval of Drs2p from the early endosome back to the trans Golgi network Saccharomyces cerevisiae 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae functional co-dependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the trans-Golgi network and early endosomes of Saccharomyces cerevisiae, Drs2p and AP-1 operate in the same pathway and that AP-1 requires Drs2p for function, Drs2p physically interacts with AP-1, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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 gene drs2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information functional co-dependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the trans-Golgi network and early endosomes of Saccharomyces cerevisiae, Drs2p and AP-1 operate in the same pathway and that AP-1 requires Drs2p for function, Drs2p physically interacts with AP-1, overview Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
Drs2p
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 Saccharomyces cerevisiae
flippase
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 Saccharomyces cerevisiae
phospholipid translocase
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 Saccharomyces cerevisiae