Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | APLT is sensitive to redox modifications of its sulfhydryl groups, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT, overview, no inhibition and phagocytosis stimulation by S-nitrosoglutathione | Homo sapiens | |
S-nitroso-L-cysteine-ethyl ester | i.e. SNCEE, causes intracellular and extracellular trans-nitrosylation of proteins, respectively. Nitrosative stress inhibits the enzyme, and SNCEE causes significant S-nitrosylation/oxidation of thiols in HL-60 cells. SNCEE also strongly inhibites APLT, activated scramblase, and causes PS externalization, reversible by DTT | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | cytosolic leaflet of the plasma membrane | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens | |
additional information | addition of Ca2+ to the incubation medium does not cause a significant increase in the scramblase activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane, nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment, involved in inflammation, reversible by DTT, overview, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | promyelocytic leukemia cells | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane, nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment, involved in inflammation, reversible by DTT, overview, macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization, reversible by DTT | Homo sapiens | ? | - |
? | |
additional information | the enzyme SCRM-1 catalyzes the externalization of phosphatidylserine to the cell surface from the inner leaflet of the plasma membrane | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminophospholipid translocase | - |
Homo sapiens |
APLT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |