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Literature summary for 7.6.2.1 extracted from
- ATP-dependent transport of phosphatidylserine analogues in human erythrocytes (2007), Biochemistry, 46, 2249-2259.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NEM | - |
Homo sapiens |  |
| vanadate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + phosphatidylserine/in | Homo sapiens | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane of erythrocytes to maintainthe lipid asymmetry, overview | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphoethanolamine/in | Homo sapiens | low activity | ADP + phosphate + phosphoethanolamine/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + N-methyl-dilauroylphosphatidyl-DL-serine/out | rapid change of cell morphology from echinocyte to stomatocyte | Homo sapiens | ADP + phosphate + N-methyl-dilauroylphosphatidyl-DL-serine/in | - |
? | |
| ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane of erythrocytes to maintainthe lipid asymmetry, overview | Homo sapiens | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphatidylserine/in | selective ATP-dependent transport of phosphatidylserine from the outer to the inner monolayer of the plasma membrane | Homo sapiens | ADP + phosphate + phosphatidylserine/out | - |
? | |
| ATP + H2O + phosphoethanolamine/in | low activity | Homo sapiens | ADP + phosphate + phosphoethanolamine/out | - |
? | |
| ATP + H2O + sn-1,2-dilauroylphosphatidyl-D-serine/out | rapid change of cell morphology from echinocyte to stomatocyte | Homo sapiens | ADP + phosphate + sn-1,2-dilauroylphosphatidyl-D-serine/in | - |
? | |
| ATP + H2O + sn-1,2-dilauroylphosphatidyl-L-serine/out | rapid change of cell morphology from echinocyte to stomatocyte | Homo sapiens | ADP + phosphate + sn-1,2-dilauroylphosphatidyl-L-serine/in | - |
? | |
| ATP + H2O + sn-2,3-dilauroylphosphatidyl-L-serine/out | low activity, slow change of cell morphology from echinocyte to stomatocyte | Homo sapiens | ADP + phosphate + sn-2,3-dilauroylphosphatidyl-L-serine/in | - |
? | |
| additional information | substrate specificity, overview, no transport of dilauroylphosphatidylcholine, poor activity with dilauroylphosphatidylhydroxypropionate, dilauroylphosphatidylhomoserine, dilauroylphosphatidylserine-methyl ester, or sn-2,3-dilauroylphosphatidyl-D-serine | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminophospholipid flippase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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