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Literature summary for 7.6.2.1 extracted from

  • Natarajan, P.; Wang, J.; Hua, Z.; Graham, T.R.
    Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function (2004), Proc. Natl. Acad. Sci. USA, 101, 10614-10619.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
protein Drs2p coupled to the enzyme, required for the translocation of phospholipids from the luminal leaflet of the membrane to the cytosolic leaflet in the trans-Golgi network, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane
-
Saccharomyces cerevisiae 139
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + phosphatidylethanolamine/out Saccharomyces cerevisiae transport from the luminal leaflet of the membrane to the cytosolic leaflet ADP + phosphate + phosphatidylethanolamine/in
-
?
ATP + H2O + phosphatidylserine/out Saccharomyces cerevisiae transport from the luminal leaflet of the membrane to the cytosolic leaflet ADP + phosphate + phosphatidylserine/in
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphatidylethanolamine/out transport from the luminal leaflet of the membrane to the cytosolic leaflet Saccharomyces cerevisiae ADP + phosphate + phosphatidylethanolamine/in
-
?
ATP + H2O + phosphatidylethanolamine/out 7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet Saccharomyces cerevisiae ADP + phosphate + phosphatidylethanolamine/in
-
?
ATP + H2O + phosphatidylserine/out transport from the luminal leaflet of the membrane to the cytosolic leaflet Saccharomyces cerevisiae ADP + phosphate + phosphatidylserine/in
-
?
ATP + H2O + phosphatidylserine/out 7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet Saccharomyces cerevisiae ADP + phosphate + phosphatidylserine/in
-
?

Synonyms

Synonyms Comment Organism
aminophospholipid translocase
-
Saccharomyces cerevisiae
APLT
-
Saccharomyces cerevisiae