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Literature summary for 7.6.2.1 extracted from

  • Noji, T.; Yamamoto, T.; Saito, K.; Fujimura-Kamada, K.; Kondo, S.; Tanaka, K.
    Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast (2006), Biochem. Biophys. Res. Commun., 344, 323-331.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information lem3 mutants are not affected in Lem3p-Dnf1p complex formation, but show a synthetic growth defect with the null mutation CDC50, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome Cdc50p-Drs2p complex Saccharomyces cerevisiae 5768
-
Golgi membrane Cdc50p-Drs2p complex Saccharomyces cerevisiae 139
-
plasma membrane Lem3p-Dnf1p complex Saccharomyces cerevisiae 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the Lem3p-Dnf1p complex can substitute for the Cdc50p-Drs2p complex, its redundant partner in the endosomal/trans-Golgi network compartments ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylcholine/out internalization through the plasma membrane by the Dnf1p-Lem3p complex Saccharomyces cerevisiae ADP + phosphate + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylcholine/in
-
 ?
ATP + H2O + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylethanolamine/out internalization through the plasma membrane by the Dnf1p-Lem3p complex Saccharomyces cerevisiae ADP + phosphate + 1-palmitoyl-2-(6-(7-nitro-2-1,3-benzoxadiazole)-aminocaproyl)-phosphatidylethanolamine/in
-
 ?
additional information the Lem3p-Dnf1p complex can substitute for the Cdc50p-Drs2p complex, its redundant partner in the endosomal/trans-Golgi network compartments Saccharomyces cerevisiae ?
-
 ?
additional information Dnf1p forms a complex with Lem3p acting as aminophospholipid translocase Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
aminophospholipid translocase
-
 Saccharomyces cerevisiae
APLT
-
 Saccharomyces cerevisiae
Cdc50p-Drs2p
-
 Saccharomyces cerevisiae
Dnf1p
-
 Saccharomyces cerevisiae
Dnf1p-Lem3p
-
 Saccharomyces cerevisiae
Drs2p
-
 Saccharomyces cerevisiae
More the enzyme belongs to the P-type ATPases Saccharomyces cerevisiae
phospholipid-translocase
-
 Saccharomyces cerevisiae