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Literature summary for 7.5.2.6 extracted from
- Lipopolysaccharide binding to the periplasmic protein LptA (2017), Protein Sci., 26, 1517-1523 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| inner membrane | an integral transmembrane protein | Escherichia coli | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + lipid A-core oligosaccharide[side 1] | Escherichia coli | - |
ADP + phosphate + lipid A-core oligosaccharide[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P60752 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + lipid A-core oligosaccharide[side 1] | - |
Escherichia coli | ADP + phosphate + lipid A-core oligosaccharide[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EcMsbA | - |
Escherichia coli |
| lipid A export ATP-binding/permease protein MsbA | UniProt | Escherichia coli |
| MsbA | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | structure comparisons and molecular basis of active lipid transport, overview | Escherichia coli |
| physiological function | the movement of core-lipopolysaccharide across the inner membrane of Gram-negative bacteria is catalysed by an essential ATP-binding cassette transporter, MsbA. The ABC transporter MsbA flips the lipid to the outer leaflet of the inner membrane and the O-antigen is attached by WaaL to create LPS. LPS and the periplasmic protein, LptA (EC 2.7.8.43), are two essential components of Gram-negative bacteria. LPS (endotoxin) is asymmetrically distributed in the outer leaflet of the outer membrane of Gram-negative bacteria such as Escherichia coli and plays a role in the organism's natural defense in adverse environmental conditions. LptA is a member of the lipopolysaccharide transport protein (Lpt) family, which also includes LptC, LptDE, and LptBFG2, that functions to transport LPS through the periplasm to the outer leaflet of the outer membrane after MsbA flips LPS across the inner membrane | Escherichia coli |
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Release 2023.1 (January 2023)
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