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Literature summary for 7.5.2.1 extracted from

  • Alvarez, F.J.; Orelle, C.; Huang, Y.; Bajaj, R.; Everly, R.M.; Klug, C.S.; Davidson, A.L.
    Full engagement of liganded maltose-binding protein stabilizes a semi-open ATP-binding cassette dimer in the maltose transporter (2015), Mol. Microbiol., 98, 878-894.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.5.2.1

Activating Compound

Activating Compound Comment Organism Structure
maltose-binding protein about 10dolf stimulation of activity at 0.005 mM Escherichia coli
additional information the enzyme activity is independent of maltose Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Escherichia coli 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + maltose/out Escherichia coli
-
 ADP + phosphate + maltose/in
-
 ?
additional information Escherichia coli stabilization of the semi-open MalK2 conformation by maltose-bound maltose-binding protein is key to the coupling of maltose transport to ATP hydrolysis in vivo, because it facilitates the progression of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyze ATP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P68187
-
-

Purification (Commentary)

Purification (Comment) Organism
cobalt resin column chromatography and Talon resin column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + maltose/out
-
 Escherichia coli ADP + phosphate + maltose/in
-
 ?
additional information stabilization of the semi-open MalK2 conformation by maltose-bound maltose-binding protein is key to the coupling of maltose transport to ATP hydrolysis in vivo, because it facilitates the progression of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyze ATP Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
MalFGK2
-
 Escherichia coli
MalK
-
 Escherichia coli