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Literature summary for 7.5.2.1 extracted from
- Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2 (2012), PLoS ONE, 7, e34836.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| substrate-binding protein MalE | binds with high-affinity to MalFGK2 and facilitate the acquisition of maltose | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + maltose/out | Escherichia coli | - |
ADP + phosphate + maltose/in | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
genes malEFG | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + maltose/out | - |
Escherichia coli | ADP + phosphate + maltose/in | - |
? | |
| ATP + H2O + maltose/out | maltose transport and ATPase activity of the MalFGK2 complex | Escherichia coli | ADP + phosphate + maltose/in | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MalFGK2 | - |
Escherichia coli |
| maltose transporter | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the maltose transporter MalFGK2, together with the substrate-binding protein MalE, is a ABC transporter. MalE is bound in the periplasm with high-affinity to MalFGK2 to facilitate the acquisition of maltose. When the maltose concentration exceeds the transport capacity, MalE captures maltose and dissociates from the transporte, from the transporter past a threshold maltose concentration, in vivo, mechanism, overview. Maltose is both substrate and regulator of its own transporter, i.e. a homotropic regulator | Escherichia coli |
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