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Literature summary for 7.4.2.7 extracted from

  • Browne, B.L.; McClendon, V.; Bedwell, D.M.
    Mutations within the first LSGGQ motif of Ste6p cause defects in alpha-factor transport and mating in Saccharomyces cerevisiae (1996), J. Bacteriol., 178, 1712-1719.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
A517T mates with wild-type efficiency at 30°C. The organism shows 2-3fold decrease in mating at 37°C Saccharomyces cerevisiae
A532H mates with wild-type efficiency at 30°C. The organism shows 2-3fold decrease in mating at 37°C Saccharomyces cerevisiae
G509D significant reduction in alpha-factor transport. The organism shows 56fold decrease in mating relative to wild-type control Saccharomyces cerevisiae
I521N mates with wild-type efficiency at 30°C. The organism shows 2-3fold decrease in mating at 37°C Saccharomyces cerevisiae
R518T mates with wild-type efficiency at 30°C. The organism shows 11fold reduction in mating at 37°C Saccharomyces cerevisiae
S507I less severe reduction in alpha-factor transport. The organism shows a mating defect at 30°C Saccharomyces cerevisiae
S507N significant reduction in alpha-factor transport. The organism shows 90fold decrease in mating relative to the wild-type control Saccharomyces cerevisiae
S507R significant reduction in alpha-factor transport. The organism shows a mating defect at 30°C Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + alpha-factor/in Saccharomyces cerevisiae enzyme is responsible for transporting the alpha-factor mating pheromone out of the cell, thus performing the final step in alpha-factor biogenesis ADP + phosphate + alpha-factor/out
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + alpha-factor/in
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Saccharomyces cerevisiae ADP + phosphate + alpha-factor/out
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?
ATP + H2O + alpha-factor/in enzyme is responsible for transporting the alpha-factor mating pheromone out of the cell, thus performing the final step in alpha-factor biogenesis Saccharomyces cerevisiae ADP + phosphate + alpha-factor/out
-
?

Synonyms

Synonyms Comment Organism
Ste6p
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Saccharomyces cerevisiae