Literature summary for 7.4.2.6 extracted from

Groshong, A.M.; Dey, A.; Bezsonova, I.; Caimano, M.J.; Radolf, J.D.
Peptide uptake is essential for Borrelia burgdorferi viability and involves structural and regulatory complexity of its oligopeptide transporter (2017), mBio, 8, e02047-17 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]	Borreliella burgdorferi	-	ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]	-	?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]	Borreliella burgdorferi B31	-	ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]	-	?

Organism

Organism	UniProt	Comment	Textmining
Borreliella burgdorferi	H7C7K8	OppA4	-
Borreliella burgdorferi B31	H7C7K8	OppA4	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]	-	Borreliella burgdorferi	ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]	-	?
ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1]	-	Borreliella burgdorferi B31	ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]	-	?
ATP + H2O + X-Ala-Ala-Ala-[X-Ala-Ala-Ala-binding protein][side 1]	-	Borreliella burgdorferi	ADP + phosphate + X-Ala-Ala-Ala[side 2] + [X-Ala-Ala-Ala-binding protein][side 1]	-	?
ATP + H2O + X-Ala-Ala-Ala-[X-Ala-Ala-Ala-binding protein][side 1]	-	Borreliella burgdorferi B31	ADP + phosphate + X-Ala-Ala-Ala[side 2] + [X-Ala-Ala-Ala-binding protein][side 1]	-	?

Synonyms

Synonyms	Comment	Organism
oligopeptide transporter	-	Borreliella burgdorferi
Opp	the Opp system consists of five oligopeptide-binding proteins (OppA1 to OppA5), two heterodimeric cytoplasmic membrane permeases (OppB1C1 and OppB2C2), and a nucleotide-binding domain heterodimer (OppDF) that drives transport by hydrolyzing ATP	Borreliella burgdorferi

General Information

General Information	Comment	Organism
malfunction	loss of enzyme function abrogates spirochete growth in vitro	Borreliella burgdorferi
physiological function	the enzyme is essential for viability, morphogenesis, and virulence within the mammalian host	Borreliella burgdorferi

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Release 2023.1 (January 2023)