Literature summary for 7.4.2.6 extracted from

Flores-Valdez, M.A.; Morris, R.P.; Laval, F.; Daffe, M.; Schoolnik, G.K.
Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system (2009), FASEB J., 23, 4091-4104.

Search for more literature for 7.4.2.6

Cloned(Commentary)

Cloned (Comment)	Organism
opp, genome-wide transcriptional profiling	Mycobacterium tuberculosis

Protein Variants

Protein Variants	Comment	Organism
additional information	mutagenesis of the permease encoded by the Rv1283c-Rv1280c genes in Mtb 1254, Rv1283c-Rv1280c genes are deleted, generation of an Opp loss of function mutant, phenotype. Disruption of the opp locus	Mycobacterium tuberculosis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	growth and virulence assessment in mice	Mycobacterium tuberculosis	-

Synonyms

Synonyms	Comment	Organism
oligopeptide permease	-	Mycobacterium tuberculosis
Opp	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
additional information	Genes Mtb Rv3666c-Rv3663c encode an Opp transport system dispensable for in vitro growth. The Opp loss of function mutant shows no in vitro growth defect, but has diminished burden during chronic infection and produces a slightly delayed time to death of animals when compared to wild-type infection. But disruption of the opp locus affects the expression of genes involved in the production of mycobacterial lipids	Mycobacterium tuberculosis
physiological function	the bacterium controls production of some exposed molecules by importing oligopeptide signals via permeases. Such oligopeptides modulate intracellular signaling pathways, overview. Also Opp is required to modulate the expression of several genes, most of them encoding surface-exposed molecules, e.g. the virulence-associated lipids mycolic acids and phthiocerol dimycocerosates, as well as PE-family proteins	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)