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Literature summary for 7.4.2.6 extracted from

  • Wu, T.K.; Wang, Y.K.; Chen, Y.C.; Feng, J.M.; Liu, Y.H.; Wang, T.Y.
    Identification of a Vibrio furnissii oligopeptide permease and characterization of its in vitro hemolytic activity (2007), J. Bacteriol., 189, 8215-8223.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene oppA, DNA and amino acid sequence determination and analysis, expression of the wild-type enzyme in Escherichia coli strain BL21(DE3) Vibrio furnissii

Protein Variants

Protein Variants Comment Organism
additional information construction of a hly-oppA knockout mutant of Vibrio furnissii, VFYKW1, by the allelic exchange method, the hly-oppA knockout mutant causes less mortality than the wild-type strain when it was inoculated into BALB/c mice, morphology and biofilm production of the hly-oppA knockout mutant, overview Vibrio furnissii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + olipopeptide/out Vibrio furnissii Hly-OppA has multiple functions in solute binding, in in vitro hemolysis, in antibiotic resistance, and as a virulence factor in bacterial pathogenesis, overview ADP + phosphate + oligopeptide/in
-
?
additional information Vibrio furnissii the purified protein exhibits host-specific in vitro hemolytic activity against various mammalian erythrocytes and apparent cytotoxicity in CHO-K1 cells ?
-
?

Organism

Organism UniProt Comment Textmining
Vibrio furnissii Q0PRU9 gene oppA
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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biofilm formation assay of wild-type and mutant strains Vibrio furnissii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + olipopeptide/out
-
Vibrio furnissii ADP + phosphate + oligopeptide/in
-
?
ATP + H2O + olipopeptide/out Hly-OppA has multiple functions in solute binding, in in vitro hemolysis, in antibiotic resistance, and as a virulence factor in bacterial pathogenesis, overview Vibrio furnissii ADP + phosphate + oligopeptide/in
-
?
additional information the purified protein exhibits host-specific in vitro hemolytic activity against various mammalian erythrocytes and apparent cytotoxicity in CHO-K1 cells Vibrio furnissii ?
-
?

Synonyms

Synonyms Comment Organism
Hly-OppA
-
Vibrio furnissii
oligopeptide permease
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Vibrio furnissii