Literature summary for 7.4.2.5 extracted from

Beale, J.H.; Parker, J.L.; Samsudin, F.; Barrett, A.L.; Senan, A.; Bird, L.E.; Scott, D.; Owens, R.J.; Sansom, M.S.; Tucker, S.J.; Meredith, D.; Fowler, P.W.; Newstead, S.
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport (2015), Structure, 23, 1889-1899.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
extracellular domain from isoform PepT1, sitting drop vapor diffusion method, using 20% (w/v) polyethylene glycol 6000, 0.1 M MES (pH 6.0), and 0.2 M ammonium chloride	Mus musculus
extracellular domain from isoform PepT2, sitting drop vapor diffusion method, using 0.2 M (NH4)3 citrate (pH 5.8) and 21% PEG (w/v) 3350	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
cefaclor	-	Mus musculus
cefaclor	-	Rattus norvegicus
L-Lys-L-Lys	-	Mus musculus
L-Lys-L-Lys	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasmic membrane	-	Rattus norvegicus	-	-
cytoplasmic membrane	-	Mus musculus	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
17100	-	2 * 17100, isoform PEPT1, X-ray crystallography	Mus musculus
20100	-	2 * 20100, isoform PEPT2, X-ray crystallography	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JIP7	-	-
Rattus norvegicus	Q63424	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + glycyl-sarcosine/in	-	Rattus norvegicus	ADP + phosphate + glycyl-sarcosine/out	-	?
ATP + H2O + glycyl-sarcosine/in	-	Mus musculus	ADP + phosphate + glycyl-sarcosine/out	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 17100, isoform PEPT1, X-ray crystallography	Mus musculus
homodimer	2 * 20100, isoform PEPT2, X-ray crystallography	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
PepT1	-	Mus musculus
PEPT2	-	Rattus norvegicus

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Release 2023.1 (January 2023)