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Literature summary for 7.4.2.5 extracted from

  • Feltcher, M.E.; Gunawardena, H.P.; Zulauf, K.E.; Malik, S.; Griffin, J.E.; Sassetti, C.M.; Chen, X.; Braunstein, M.
    Label-free quantitative proteomics reveals a role for the Mycobacterium tuberculosis SecA2 pathway in exporting solute binding proteins and Mce transporters to the cell wall (2015), Mol. Cell. Proteomics, 14, 1501-1516.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGP3
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-
Mycobacterium tuberculosis H37Rv P9WGP3
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-

Synonyms

Synonyms Comment Organism
SecA2
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 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function role for the SecA2 pathway in the cell wall localization of solute binding proteins that work with ABC transporters to import solutes. Additionally, SecA2 has a profound effect on the cell wall localization of the Mce1 and Mce4 lipid transporters, which contribute to Mycobacterium tuberculosis virulence. A relationship exists between SecA2 and the hypoxia-induced DosR regulon associated with Mycobacterium tuberculosis latency. Nearly half of the transcriptionally controlled DosR regulon of cytoplasmic proteins are detected at higher levels in the secA2 mutant versus wild-type Mycobacterium tuberculosis