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Literature summary for 7.4.2.5 extracted from

  • Tumulka, F.; Roos, C.; Loehr, F.; Bock, C.; Bernhard, F.; Doetsch, V.; Abele, R.
    Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR (2013), J. Biomol. NMR, 57, 141-154.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + peptide/in Homo sapiens the enzyme translocates cytosolic peptides into the lumen of lysosomes driven by the hydrolysis of ATP ADP + phosphate + peptide/out
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NP78
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni–NTA agarose column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + peptide/in the enzyme translocates cytosolic peptides into the lumen of lysosomes driven by the hydrolysis of ATP Homo sapiens ADP + phosphate + peptide/out
-
?

Synonyms

Synonyms Comment Organism
ABCB9
-
Homo sapiens
peptide transporter
-
Homo sapiens
TAPL
-
Homo sapiens