Literature summary for 7.4.2.5 extracted from

Poirier, A.; Belli, S.; Funk, C.; Otteneder, M.B.; Portmann, R.; Heinig, K.; Prinssen, E.; Lazic, S.E.; Rayner, C.R.; Hoffmann, G.; Singer, T.; Smith, D.E.; Schuler, F.
Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies (2012), Drug Metab. Dispos., 40, 1556-1565.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Chinese hamster ovary cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Homo sapiens	-
intestine	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + oseltamivir carboxylate/in	the enzyme is not implicated in the oral absorption of oseltamivir carboxylate	Homo sapiens	ADP + phosphate + oseltamivir carboxylate/out	-	?
ATP + H2O + oseltamivir carboxylate/in	the enzyme is not implicated in the oral absorption of oseltamivir carboxylate	Rattus norvegicus	ADP + phosphate + oseltamivir carboxylate/out	-	?
ATP + H2O + oseltamivir/in	the enzyme is not implicated in the oral absorption of oseltamivir	Homo sapiens	ADP + phosphate + oseltamivir/out	-	?
ATP + H2O + oseltamivir/in	the enzyme is not implicated in the oral absorption of oseltamivir	Rattus norvegicus	ADP + phosphate + oseltamivir/out	-	?

Synonyms

Synonyms	Comment	Organism
PepT1	-	Homo sapiens
PepT1	-	Rattus norvegicus
peptide transporter 1	-	Homo sapiens
peptide transporter 1	-	Rattus norvegicus

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Release 2023.1 (January 2023)