Literature summary for 7.4.2.5 extracted from

Dalal, K.; Chan, C.S.; Sligar, S.G.; Duong, F.
Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase (2012), Proc. Natl. Acad. Sci. USA, 109, 4104-4109.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

General Information

General Information	Comment	Organism
physiological function	SecA ATPase associates with the SecY complex to push preproteins across the bacterial membrane. One SecY copy is sufficient to bind SecA and the preprotein, but only the SecY dimer together with acidic lipids supports the activation of the SecA translocation ATPase. In nanodiscs, the dimer is predominantly arranged in a back-to-back manner and remains active even if a constituent SecY copy is defective for SecA binding. In membrane vesicles and in intact cells, the coproduction of two inactive SecYs, one for channel gating and the other for SecA binding, recreates a functional translocation unit	Escherichia coli

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Release 2023.1 (January 2023)