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Literature summary for 7.4.2.5 extracted from

  • Flaten, G.; Kottra, G.; Stensen, W.; Isaksen, G.; Karstad, R.; Svendsen, J.; Daniel, H.; Svenson, J.
    In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides (2011), J. Med. Chem., 54, 2422-2432.
    View publication on PubMed
Search for more literature for 7.4.2.5

Cloned(Commentary)

Cloned (Comment) Organism
expression in Xenopus laevis oocytes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-biphenyl-L-alanyl-L-arginine methyl ester peptide derived from lactoferricin, at 1 mM, 10% inhibition of glycylsarcosine-induced current Homo sapiens
RWR-NH(benzyl) peptide derived from lactoferricin, at 1 mM, 87% inhibition of glycylsarcosine-induced current, peptide can also impair membrane protein functions in an unspecific manner Homo sapiens
RWR-NH2 peptide derived from lactoferricin, at 1 mM, 15% inhibition of glycylsarcosine-induced current Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information permeation of cationic antimicrobial di- and tripeptides derived from lactoferricin and test for interaction with PEPT1, none serves as a substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PepT1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7
-
 pH 7.4, 22°C Homo sapiens RWR-NH2