Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine) | - |
Escherichia coli | |
2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine) | compound does not show antimicrobial activity | Escherichia coli | |
2-(benzylsulfanyl)-4-(biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | exhibits most potent inhibition effects against strain NR698 with increased outer membrane permeability | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
EcN68, the N-terminal fragment of SecA without the C-terminal regulatory domain, pH 7.6, 40°C | Escherichia coli | 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine) | |
0.002 | - |
EcN68, the N-terminal fragment of SecA without the C-terminal regulatory domain, pH 7.6, 40°C | Escherichia coli | 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine) | |
0.02 | - |
recombinant SecA, pH 7.6, 40°C | Escherichia coli | 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine) | |
0.05 | - |
recombinant SecA, pH 7.6, 40°C | Escherichia coli | 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine) | |
0.06 | - |
recombinant SecA, pH 7.6, 40°C | Escherichia coli | 2-(benzylsulfanyl)-4-(biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile |