Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.4.2.5 extracted from

  • Chen, W.; Huang, Y.; Reddy Gundala, S.; Yang, H.; Li, N.; Tai, P.C.; Wang, B.
    The first low microM SecA inhibitors (2010), Bioorg. Med. Chem., 18, 1617-1625.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine)
-
Escherichia coli
2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine) compound does not show antimicrobial activity Escherichia coli
2-(benzylsulfanyl)-4-(biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile exhibits most potent inhibition effects against strain NR698 with increased outer membrane permeability Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
EcN68, the N-terminal fragment of SecA without the C-terminal regulatory domain, pH 7.6, 40°C Escherichia coli 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine)
0.002
-
EcN68, the N-terminal fragment of SecA without the C-terminal regulatory domain, pH 7.6, 40°C Escherichia coli 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine)
0.02
-
recombinant SecA, pH 7.6, 40°C Escherichia coli 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(4-bromophenyl)-5-cyano-4-oxopyrimidine)
0.05
-
recombinant SecA, pH 7.6, 40°C Escherichia coli 2,2'-(alpha,alpha'-xylene)bis(sulfanediyl)bis-(6-(biphenyl-4-yl)-5-cyano-4-oxopyrimidine)
0.06
-
recombinant SecA, pH 7.6, 40°C Escherichia coli 2-(benzylsulfanyl)-4-(biphenyl-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile