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Literature summary for 7.4.2.5 extracted from
- Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells (2008), Biol. Pharm. Bull., 31, 1-5.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme 12A, expression of TAPL in membranes of Drosophila melanogaster S2 cells | Homo sapiens |
| isozyme 12A, expression of TAPL in membranes of Drosophila melanogaster S2 cells | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
| Mg2+ | required | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + peptide/in | Homo sapiens | - |
ADP + phosphate + peptide/out | - |
? | |
| ATP + H2O + peptide/in | Rattus norvegicus | - |
ADP + phosphate + peptide/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozyme 12A | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant TAPL from membranes of Drosophila melanogaster S2 cells by detergent solubilization, and ADP or ATP affinity chromatography, not by AMP affinity | Homo sapiens |
| recombinant TAPL from membranes of Drosophila melanogaster S2 cells by detergent solubilization, and ADP or ATP affinity chromatography, not by AMP affinity | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O + peptide/in | - |
Homo sapiens | AMP + phosphate + peptide/out | - |
? | |
| ADP + H2O + peptide/in | - |
Rattus norvegicus | AMP + phosphate + peptide/out | - |
? | |
| ATP + H2O + peptide/in | - |
Homo sapiens | ADP + phosphate + peptide/out | - |
? | |
| ATP + H2O + peptide/in | - |
Rattus norvegicus | ADP + phosphate + peptide/out | - |
? | |
| GTP + H2O + peptide/in | - |
Homo sapiens | GDP + phosphate + peptide/out | - |
? | |
| GTP + H2O + peptide/in | - |
Rattus norvegicus | GDP + phosphate + peptide/out | - |
? | |
| additional information | the enzyme binds ATP, ADP, GTP, and dATP, UTP, and CTP to a lower extent, but not AMP | Homo sapiens | ? | - |
? | |
| additional information | the enzyme binds ATP, ADP, GTP, and dATP, UTP, and CTP to a lower extent, but not AMP | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | TAPL forms a homodimer in the membrane and under the solubilized conditions | Homo sapiens |
| homodimer | TAPL forms a homodimer in the membrane and under the solubilized conditions | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB9 | - |
Homo sapiens |
| ABCB9 | - |
Rattus norvegicus |
| TAPL | - |
Homo sapiens |
| TAPL | - |
Rattus norvegicus |
| transporter associated with antigen processing-like | - |
Homo sapiens |
| transporter associated with antigen processing-like | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Homo sapiens | |
| ADP | - |
Rattus norvegicus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
| GTP | - |
Homo sapiens | |
| GTP | - |
Rattus norvegicus | |
| additional information | no activity with AMP | Homo sapiens | |
| additional information | no activity with AMP | Rattus norvegicus |
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