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Literature summary for 7.4.2.5 extracted from

  • Chen, M.; Abele, R.; Tampe, R.
    Functional non-equivalence of ATP-binding cassette signature motifs in the transporter associated with antigen processing (TAP) (2004), J. Biol. Chem., 279, 46073-46081.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information mutant pairs of TAP1/TAP2 with mutation in ABC signature motif, C-loop. Chimera with two canonical C-loops show highest transport activity, chimera with two degenerate C-loops have lowest transport rates. All single mutants and chimera show similar activities in peptide or ATP binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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ATPase activity associated with transporter associated with antigen processing, TAP
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