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Literature summary for 7.4.2.5 extracted from

  • Howard, S.P.; Meiklejohn, H.G.; Shivak, D.; Jahagirdar, R.
    A TonB-like protein and a novel membrane protein containing an ATP-binding cassette function together in exotoxin secretion (1996), Mol. Microbiol., 22, 595-604.
    View publication on PubMed
Search for more literature for 7.4.2.5

Cloned(Commentary)

Cloned (Comment) Organism
exeA, subcloned into pEI14b, expressed in Escherichia coli Aeromonas hydrophila

Protein Variants

Protein Variants Comment Organism
G55A mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila
G55D mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila
G55V mutation in the potential ATP-binding site in ExeA, decreased rate of aerolysin secretion Aeromonas hydrophila

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane inner membrane detected by immunoblotting, ExeA, cytoplasmic domain with ATP-binding site Aeromonas hydrophila 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + aerolysin/in Aeromonas hydrophila
-
 ADP + phosphate + aerolysin/out
-
 ?

Organism

Organism UniProt Comment Textmining
Aeromonas hydrophila
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ExeA Aeromonas hydrophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + aerolysin/in
-
 Aeromonas hydrophila ADP + phosphate + aerolysin/out
-
 ?

Subunits

Subunits Comment Organism
More ABC transporter Aeromonas hydrophila
More ExeA, cytoplasmic domain with ATP-binding site Aeromonas hydrophila