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Literature summary for 7.4.2.13 extracted from

  • Steglich, M.; Hofmann, J.D.; Helmecke, J.; Sikorski, J.; Spröer, C.; Riedel, T.; Bunk, B.; Overmann, J.; Neumann-Schaal, M.; Nübel, U.
    Convergent loss of ABC transporter genes from Clostridioides difficile genomes is associated with impaired tyrosine uptake and p-cresol production (2018), Front. Microbiol., 9, 901 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.13

Protein Variants

Protein Variants Comment Organism
additional information frequent, convergent loss of genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. The genomic deletion is strongly associated with the reduced uptake of tyrosine and phenylalanine and production of derived Stickland fermentation products, including p-cresol. The transporter gene loss does not measurably affect bacterial growth or production of enterotoxins. The gene deletion has occurred multiple times in diverse clonal lineages of Clostridioides difficile, with a particularly high prevalence in ribotype 027 isolates Clostridioides difficile

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Clostridioides difficile 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28049
-
 ATP-binding protein, calculation from sequence Clostridioides difficile
36970
-
 substrate-binding lipoprotein, calculation from sequence Clostridioides difficile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1] Clostridioides difficile
-
 ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1]
-
 ir
ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1] Clostridioides difficile R20291
-
 ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1]
-
 ir

Organism

Organism UniProt Comment Textmining
Clostridioides difficile A0A8E2P6N8 AND A0A489KKB9 C9YJQ5 i.e. substrate-binding lipoprotein, C9YJQ6 i.e. ATP-binding protein
-
Clostridioides difficile R20291 A0A8E2P6N8 AND A0A489KKB9 C9YJQ5 i.e. substrate-binding lipoprotein, C9YJQ6 i.e. ATP-binding protein
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-phenylalaninyl-[tyrosine-binding protein][side 1]
-
 Clostridioides difficile ADP + phosphate + L-phenylalanine[side 2] + [tyrosine-binding protein][side 1]
-
 ir
ATP + H2O + L-phenylalaninyl-[tyrosine-binding protein][side 1]
-
 Clostridioides difficile R20291 ADP + phosphate + L-phenylalanine[side 2] + [tyrosine-binding protein][side 1]
-
 ir
ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1]
-
 Clostridioides difficile ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1]
-
 ir
ATP + H2O + L-tyrosinyl-[tyrosine-binding protein][side 1]
-
 Clostridioides difficile R20291 ADP + phosphate + L-tyrosine[side 2] + [tyrosine-binding protein][side 1]
-
 ir

Synonyms

Synonyms Comment Organism
CDR20291_0805 gene name substrate-binding lipoprotein Clostridioides difficile
CDR20291_0806 gene name, ATP-binding protein Clostridioides difficile

General Information

General Information Comment Organism
physiological function the loss of genes encoding the substrate-binding protein and the ATP-binding protein is strongly associated with the reduced uptake of tyrosine and production of derived Stickland fermentation products, including p-cresol Clostridioides difficile