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Literature summary for 7.4.2.12 extracted from

  • Ohtsu, I.; Kawano, Y.; Suzuki, M.; Morigasaki, S.; Saiki, K.; Yamazaki, S.; Nonaka, G.; Takagi, H.
    Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli (2015), PLoS ONE, 10, e0120619 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.4.2.12

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000496
-
 L-cystine-[cystine-binding protein][side 1] at pH 6.5 and 37°C Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-cystine-[cystine-binding protein][side 1] Escherichia coli
-
 ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-cystine-[cystine-binding protein][side 1]
-
 Escherichia coli ADP + phosphate + L-cystine[side 2] + [cystine-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
FliY-YecSC
-
 Escherichia coli
L-cystine transporter
-
 Escherichia coli

Expression

Organism Comment Expression
Escherichia coli enzyme expression is induced by H2O2 up

General Information

General Information Comment Organism
metabolism the enzyme imports L-cystine from the periplasm to the cytoplasm Escherichia coli
physiological function the enzyme contributes to hydrogen peroxide tolerance. The L-cystine/L-cystine shuttle system plays a role of detoxification of hydrogen peroxide before lipid peroxidation occurs, and then specifically prevents damage to membrane lipids Escherichia coli