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Literature summary for 7.4.2.12 extracted from

  • Vergauwen, B.; Verstraete, K.; Senadheera, D.B.; Dansercoer, A.; Cvitkovitch, D.G.; Guedon, E.; Savvides, S.N.
    Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans (2013), Mol. Microbiol., 89, 288-303 .
    View publication on PubMed
Search for more literature for 7.4.2.12

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Streptococcus mutans 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1) Streptococcus mutans
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1) Streptococcus mutans UA159
-
 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-
Streptococcus mutans UA159
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
-
 Streptococcus mutans ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?
ATP + H2O + L-cystine-[cystine-binding protein TcyA](side 1)
-
 Streptococcus mutans UA159 ADP + phosphate + L-cystine(side 2) + [cystine-binding protein TcyA](side 1)
-
 ?

Synonyms

Synonyms Comment Organism
cystine ABC importer
-
 Streptococcus mutans
cystine-specific ABC transporter
-
 Streptococcus mutans
tcyABC
-
 Streptococcus mutans
TcyB transmembrane permease component Streptococcus mutans
TcyC ATPase component Streptococcus mutans

General Information

General Information Comment Organism
physiological function the enzyme is required for growth of Streptococcus mutans on glutathione as the sole source of sulfur Streptococcus mutans