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Literature summary for 7.4.2.1 extracted from

  • Gao, M.; Kaiser, C.A.
    A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast (2006), Nat. Cell Biol., 8, 657-667.
    View publication on PubMed

Application

Application Comment Organism
additional information identification of a GTPase-containing complex for Gap1p sorting in the endosomes, which has a key role in trafficking Gap1p out of the late endosome and may serve as coat proteins in this process, the complex contains the GTPases Gtr1p and Gtr2p, delivery of Gap1p to the plasma membrane depends on specific nucleotide-bound states of the GTPases, Gtr2p interacts with the C-terminal cytosolic domain of Gap1p, a tyrosine-containing motif in this domain is necessary both to bind Gtr2p and to direct sorting of Gap1p to the plasma membrane Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Saccharomyces cerevisiae 5737
-
endosome
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Saccharomyces cerevisiae 5768
-
plasma membrane
-
Saccharomyces cerevisiae 5886
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
strains isogenic to S288C
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Synonyms

Synonyms Comment Organism
Gap1p
-
Saccharomyces cerevisiae
general amino acid permease
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Saccharomyces cerevisiae