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Literature summary for 7.4.2.1 extracted from

  • Zhao, Q.; Chang, X-b.
    Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein MRP1 (2004), J. Biol. Chem., 279, 48505-48512.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Spodoptera frugiperda 21 Homo sapiens

Protein Variants

Protein Variants Comment Organism
W653C decreased ATP-dependent LTC4 transport Homo sapiens
W653Y higher transport activity than wild-type enzyme Homo sapiens
Y1302C decreased ATP-dependent LTC4 transport Homo sapiens
Y1302W no effect of ATP binding and hydrolysis Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.046
-
ATP 30°C, pH 7.5, W653Y Homo sapiens
0.047
-
ATP 30°C, pH 7.5, Y1302W Homo sapiens
0.065
-
ATP 30°C, pH 7.5, W653Y/Y1302W Homo sapiens
0.069
-
ATP 30°C, pH 7.5, wild-type MRP1 Homo sapiens
0.29
-
ATP 30°C, pH 7.5, W653C/Y1302W Homo sapiens
0.311
-
ATP 30°C, pH 7.5, W653C Homo sapiens
0.34
-
ATP 30°C, pH 7.5, Y1302C Homo sapiens
0.395
-
ATP 30°C, pH 7.5, W653Y/Y1302C Homo sapiens
1.573
-
ATP 30°C, pH 7.5, W653C/Y1302C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + histidine/out Homo sapiens
-
ADP + phosphate + histidine/in
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + histidine/out
-
Homo sapiens ADP + phosphate + histidine/in
-
?

Synonyms

Synonyms Comment Organism
histidine permease
-
Homo sapiens