Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.3.2.7 extracted from

  • Lin, Y.F.; Yang, J.; Rosen, B.P.
    ArsD: an As(III) metallochaperone for the ArsAB As(III)-translocating ATPase (2007), J. Bioenerg. Biomembr., 39, 453-458.
    View publication on PubMed
Search for more literature for 7.3.2.7

Activating Compound

Activating Compound Comment Organism Structure
ArsD ArsD is an arsenic metallochaperone that delivers As(III) to the ArsA ATPase of the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite, mutational analysis of metalloid binding sites involved in As(III) transport and resistance, overview Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + arsenite/in Escherichia coli ArsA ATPase is the catalytic subunit of the ArsAB pump, ArsD is an arsenic chaperone to the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite ADP + phosphate + arsenite/out
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene arsA encoded on the ars operon on plasmid R773
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + arsenite/in ArsA ATPase is the catalytic subunit of the ArsAB pump, ArsD is an arsenic chaperone to the ArsAB pump, transferring the trivalent metalloids As(III) and Sb(III) to the ArsA subunit of the pump thereby increasing the affinity of ArsA for As(III), resulting in increased rates if extrusion and resistance to environmentally relevant concentrations of arsenite Escherichia coli ADP + phosphate + arsenite/out
-
 ?
ATP + H2O + arsenite/in ArsA ATPase is the catalytic subunit of the ArsAB pump Escherichia coli ADP + phosphate + arsenite/out
-
 ?

Synonyms

Synonyms Comment Organism
ArsAB
-
 Escherichia coli
As(III)-translocating ATPase
-
 Escherichia coli