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Literature summary for 7.3.2.1 extracted from

  • Li, X.; Yang, H.Y.; Giachelli, C.M.
    Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification (2006), Circ. Res., 98, 905-912.
    View publication on PubMed
Search for more literature for 7.3.2.1

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of Pit-1 in immortalized human aortic smooth muscle cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information smooth muscle cells expressing small interfering RNA show decreased Pit-1 mRNA and protein levels and reduced sodium-dependent phosphate transport activity compared with the control transduced cells, phosphate-induced smooth muscle cell calcification is significantly inhibited in smooth muscle cell-siRNA, and the siRNA-cells are not less susceptible to cell death than cells containing normal levels of Pit-1, overexpression of murine wild-type Pit-1 restores phosphate uptake and phosphate-induced calcification in human Pit-1 deficient cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + phosphate/out Homo sapiens Pit-1 is required for elevated phosphate-induced osteogenic gene expression in human smooth muscle cells, role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification, overview ADP + phosphate + phosphate/in
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell expression of Pit-1 and Pit-2, Pit-1 is not a component of matrix vesicles or apoptotic bodies, expression analysis, Pit-1 is the predominant sodium-dependent phosphate cotransporter, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + phosphate/out
-
 Homo sapiens ADP + phosphate + phosphate/in
-
 ?
ATP + H2O + phosphate/out Pit-1 is required for elevated phosphate-induced osteogenic gene expression in human smooth muscle cells, role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification, overview Homo sapiens ADP + phosphate + phosphate/in
-
 ?

Synonyms

Synonyms Comment Organism
PiT-1
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 Homo sapiens
sodium-dependent phosphate cotransporter
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 Homo sapiens
type III sodium-dependent phosphate cotransporter
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 Homo sapiens