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Literature summary for 7.2.4.2 extracted from

  • Dimroth, P.; Thomer, A.
    Kinetic analysis of the reaction mechanism of oxaloacetate decarboxylase from Klebsiella aerogenes (1986), Eur. J. Biochem., 156, 157-162.
    View publication on PubMed
Search for more literature for 7.2.4.2

Inhibitors

Inhibitors Comment Organism Structure
2-Oxomalonate Ki: 0.06 mM Klebsiella aerogenes
glyoxylate Ki: 0.04 mM Klebsiella aerogenes
oxalate Ki: 0.0035 Klebsiella aerogenes
pyruvate product inhibition competitive for oxaloacetate, Ki: 1.3 mM, noncompetitive inhibition for Na+, Ki: 2 mM Klebsiella aerogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Klebsiella aerogenes 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Li+ Km: 25 mM Klebsiella aerogenes
Na+ Km: 1.5 mM Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
oxaloacetate Klebsiella aerogenes
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information transmembrane transport of Na+ Klebsiella aerogenes ?
-
 ?
Oxaloacetate reaction mechanism Klebsiella aerogenes Pyruvate + CO2
-
 ?
oxaloacetate
-
 Klebsiella aerogenes ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 only if protected by oxalate Klebsiella aerogenes

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0035
-
 oxalate
-
 Klebsiella aerogenes
0.04
-
 glyoxylate
-
 Klebsiella aerogenes
0.06
-
 2-Oxomalonate
-
 Klebsiella aerogenes
1.3
-
 pyruvate product inhibition competitive for oxaloacetate Klebsiella aerogenes