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Literature summary for 7.2.2.9 extracted from
- Copper-transporting ATPase is important for malaria parasite fertility (2014), Mol. Microbiol., 91, 315-325.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium berghei | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CuTP | - |
Plasmodium berghei |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a loss-of-function mutant line shows no apparent defect in in vivo blood stage growth. Parasite transmission through the mosquito vector is severely affected, but not entirely abolished. Male and female gametocytes are abundant in mutant parasites, but activation of male microgametes and exflagellation are strongly impaired. This defect can be mimicked by addition of the copper chelator neocuproine to wild-type gametocytes. Female fertility is also severely abrogated | Plasmodium berghei |
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