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Literature summary for 7.2.2.9 extracted from

  • Valverde, R.H.; Britto-Borges, T.; Lowe, J.; Einicker-Lamas, M.; Mintz, E.; Cuillel, M.; Vieyra, A.
    Two serine residues control sequential steps during catalysis of the yeast copper ATPase through different mechanisms that involve kinase-mediated phosphorylations (2011), J. Biol. Chem., 286, 6879-6889.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
S258A the mutation abrogates all cAMP-dependent protein kinase-mediated phosphorylations of the enzyme (with an 8fold decrease in the burst of initial phosphorylation) Saccharomyces cerevisiae
S258A/S971A the mutations lead to an increase in its cAMP-dependent protein kinase-mediated global regulatory phosphorylation Saccharomyces cerevisiae
S258D the phosphomimetic mutant exhibits extremely slow phosphorylation Saccharomyces cerevisiae
S971A the mutation leads to a 100% increase in its cAMP-dependent protein kinase-mediated global regulatory phosphorylation Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Saccharomyces cerevisiae 5794
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 x * 110000, SDS-PAGE Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38995
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme undergoes auto-phosphorylation on Asp627 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Saccharomyces cerevisiae ADP + phosphate + Cu2+/out
-
 ?

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Ccc2
-
 Saccharomyces cerevisiae
copper-transporting ATPase
-
 Saccharomyces cerevisiae
Cu(I)-ATPase
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme pumps copper from the cytosol to the Golgi lumen Saccharomyces cerevisiae