Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E1064A | the mutation abolishes ATP binding to the N-domain. In the cell, neither the stability nor targeting of mutant E1064A to the trans-Golgi network differs significantly from the wild type enzyme | Homo sapiens |
H1069Q | thermolabile mutant with impaired ATP binding. The mutation greatly destabilizes protein both in vitro and in cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | trans-Golgi network | Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35670 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7B | - |
Homo sapiens |
copper-transporting ATPase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Wilson disease is caused by mutations in the Cu-transporting ATPase ATP7B | Homo sapiens |