Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.9 extracted from

  • Ibricevic, A.; Brody, S.L.; Youngs, W.J.; Cannon, C.L.
    ATP7B detoxifies silver in ciliated airway epithelial cells (2010), Toxicol. Appl. Pharmacol., 243, 315-322.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Mus musculus
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57B6/J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of ATP7A, not of ATP7B Mus musculus
-
epithelial cell airway, cell type-specific expression of ATP7A and ATP7B in airway epithelial cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Mus musculus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Mus musculus
ATP7B
-
 Mus musculus
copper transporting P-type ATPase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function expression of the copper transporter ATP7B in ciliated airway cells is required for detoxification of the methylated caffeine silver acetate compound, SCC1, in the airway epithelium. The cytotoxicity of SCC1-treated airway epithelial cell cultures derived from either wild type or ATP7B null mice littermates is compared, loss of total cells and ciliated cells is significantly greater in ATP7B-/- than in wild type airway epithelial cell Mus musculus