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Literature summary for 7.2.2.9 extracted from

  • Braiterman, L.; Nyasae, L.; Guo, Y.; Bustos, R.; Lutsenko, S.; Hubbard, A.
    Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B (2009), Am. J. Physiol. Gastrointest. Liver Physiol., 296, G433-G444.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Protein Variants

Protein Variants Comment Organism
D40A site-directed mutagenesis, inactive mutant Homo sapiens
E45A site-directed mutagenesis, inactive mutant Homo sapiens
F37A site-directed mutagenesis, the mutant is partially copper-responsive Homo sapiens
F39A site-directed mutagenesis, inactive mutant Homo sapiens
F39W site-directed mutagenesis, inactive mutant Homo sapiens
G43A site-directed mutagenesis, inactive mutant Homo sapiens
additional information construction of a truncated version of ATPB7 lacking the first 33 amino acids, the mutant behaves like the full-length enzyme Homo sapiens
N41A site-directed mutagenesis, the mutant is partially copper-responsive Homo sapiens
N41S site-directed mutagenesis, the mutant is partially copper-responsive Homo sapiens
V42A site-directed mutagenesis, inactive mutant Homo sapiens
Y44A site-directed mutagenesis, inactive mutant Homo sapiens
Y44W site-directed mutagenesis, the mutant is partially copper-responsive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens ATP7B is a copper-transporting P-type ATPase present predominantly in liver, hepatic ATPB7 loads cytoplasmic Cu2+ onto newly synthesized ceruloplasmin, the F37-E45 signal sequence is required in vivo, overview ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver ATPB7 predominantly Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in ATP7B is a copper-transporting P-type ATPase present predominantly in liver, hepatic ATPB7 loads cytoplasmic Cu2+ onto newly synthesized ceruloplasmin, the F37-E45 signal sequence is required in vivo, overview Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7B
-
 Homo sapiens
copper-ATPase
-
 Homo sapiens
copper-transporting P-type
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens