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Literature summary for 7.2.2.9 extracted from

  • Schlief, M.L.; West, T.; Craig, A.M.; Holtzman, D.M.; Gitlin, J.D.
    Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity (2006), Proc. Natl. Acad. Sci. USA, 103, 14919-14924.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Application

Application Comment Organism
medicine studies on pathogenesis and treatment of Menkes disease Rattus norvegicus
medicine studies on pathogenesis and treatment of Menkes disease Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Rattus norvegicus
-
 ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in Mus musculus
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430 transgenic mouse model of Menkes disease
-
Rattus norvegicus P70705 18-day old embryos
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
hippocampus primary hippocampal neurons Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 connection between copper homeostasis and NMDA receptor activity, ATP7A required for copper-dependent effects Rattus norvegicus
additional information
-
 connection between copper homeostasis and NMDA receptor activity, ATP7A required for copper-dependent effects Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Rattus norvegicus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in
-
 Mus musculus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in role of ATP7A in protective effect of copper in neuronal cells Mus musculus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in role of ATP7A in protective effect of copper in neuronal cells analyzed Rattus norvegicus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Rattus norvegicus
ATP7A
-
 Mus musculus
Menkes copper-transporting ATPase
-
 Rattus norvegicus
Menkes copper-transporting ATPase
-
 Mus musculus