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Literature summary for 7.2.2.9 extracted from

  • Burke, R.; Commons, E.; Camakaris, J.
    Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues (2008), Int. J. Biochem. Cell Biol., 40, 1850-1860.
    View publication on PubMed
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
Drosophila transformation vector pW8 used, generation of transgenic lines and construction of a EYFP-DmATP7 fusion protein for localization studies described Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane at or proximal to basolateral plasma membrane of midgut cells Drosophila melanogaster 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Drosophila melanogaster
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VYT4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
midgut larval stage, copper-inducible Drosophila melanogaster
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neuron main neurons of leg, wing margin, labellum, maxillary palps and third antennal segment Drosophila melanogaster
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 enhancer element with sufficient regulatory information to rescue DmATP7 mutant flies to adulthood, regulation of DmATP7 expression shown to be not used to limit copper absorption in toxic copper conditions, functional role for copper transport in neuronal tissues indicated, role for export of copper from midgut cells supported by localization studies Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Drosophila melanogaster ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in neuronal and copper-inducible expression of DmATP7 reporter gene, role for DmATP7 in export of copper from midgut cells and for copper transport in neuronal tissues Drosophila melanogaster ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7
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 Drosophila melanogaster