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Literature summary for 7.2.2.9 extracted from

  • Owatari, S.; Akune, S.; Komatsu, M.; Ikeda, R.; Firth, S.D.; Che, X.F.; Yamamoto, M.; Tsujikawa, K.; Kitazono, M.; Ishizawa, T.; Takeuchi, T.; Aikou, T.; Mercer, J.F.; Akiyama, S.; Furukawa, T.
    Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer (2007), Cancer Res., 67, 4860-4868.
    View publication on PubMed
Search for more literature for 7.2.2.9

Application

Application Comment Organism
drug development ATP7A shown to confer resistance to various anticancer agents on cancer cells, discussed as a good index of drug resistance in clinical colon cancers Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO-K1 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi trans face important role of Golgi network for ATP7A-related multidrug resistance Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04656
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell ATP7A shown to be expressed in 23.5% of clinical colon cancer specimens but not in the adjacent normal epithelium Homo sapiens
-
fibroblast isolated from Menkes disease patients, transfection with ATP7A Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 histoculture drug response assay for prediction of drug sensitivity of clinical cancers applied, ATP7A expression shown to enhance efflux rates of doxorubicin and 7-ethyl-10-hydroxy-camptothecin (SN-38) from cells, increased uptake of 7-ethyl-10-hydroxy-camptothecin in membrane vesicles indicated, ATP7A-expressing colon cancer cells shown to be more resistant to 7-ethyl-10-hydroxy-camptothecin than ATP7A-negative cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in involvement of ATP7A in multidrug resistance by compartmentalizing of drugs in the Golgi apparatus shown Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
Menkes copper-transporting ATPase
-
 Homo sapiens