Application | Comment | Organism |
---|---|---|
medicine | studies on diseases of copper deficiency or excess | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | 2 week old mice, vicinity of the basolateral membrane | Mus musculus | 16020 | - |
microsome | 20 week old mice, predominantly in intracellular vesicles | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Mus musculus | - |
ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64430 | - |
- |
Mus musculus | Q64446 | ATP7B; 2 weeks old and 20 weeks old, wild-type and deficient in copper-transporting ATPase ATP7B (-/-) | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | basolateral membrane, intracellular vesicles | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
ATP7A xpressed to a variable degree throughout the kidney, age-dependent intracellular localization, copper elevation results in the in vivo redistribution of ATP7A from intracellular compartments toward the basolateral membrane, ATP7A plays a major role in exporting copper via basolateral membranes and protects renal tissue against copper overload | Mus musculus |
additional information | - |
renal copper homeostasis requires functional ATP7B, coexpression with ATP7A, kidneys of ATP7b(-/-) mice reveals metabolic alterations manifested by the appearance of highly fluorescent deposits, lack of notable copper accumulation in the Atp7b(-/-) kidney due to compensatory export of copper by ATP7A | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Mus musculus | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | age-dependent expression studies in kidney, role for ATP7A in renal response to changes in copper load | Mus musculus | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | role for ATP7B in regulation of renal copper shown | Mus musculus | ADP + phosphate + Cu2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP7A | - |
Mus musculus |
ATP7B | - |
Mus musculus |