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BRENDA support

Literature summary for 7.2.2.9 extracted from

  • Linz, R.; Barnes, N.L.; Zimnicka, A.M.; Kaplan, J.H.; Eipper, B.; Lutsenko, S.
    Intracellular targeting of copper-transporting ATPase ATP7A in a normal and ATP7b-/- kidney (2008), Am. J. Physiol. Renal Physiol., 294, F53-F61.
    View publication on PubMed

Application

Application Comment Organism
medicine studies on diseases of copper deficiency or excess Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane 2 week old mice, vicinity of the basolateral membrane Mus musculus 16020
-
microsome 20 week old mice, predominantly in intracellular vesicles Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Mus musculus
-
ADP + phosphate + Cu2+/out
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430
-
-
Mus musculus Q64446 ATP7B; 2 weeks old and 20 weeks old, wild-type and deficient in copper-transporting ATPase ATP7B (-/-)
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney basolateral membrane, intracellular vesicles Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
ATP7A xpressed to a variable degree throughout the kidney, age-dependent intracellular localization, copper elevation results in the in vivo redistribution of ATP7A from intracellular compartments toward the basolateral membrane, ATP7A plays a major role in exporting copper via basolateral membranes and protects renal tissue against copper overload Mus musculus
additional information
-
renal copper homeostasis requires functional ATP7B, coexpression with ATP7A, kidneys of ATP7b(-/-) mice reveals metabolic alterations manifested by the appearance of highly fluorescent deposits, lack of notable copper accumulation in the Atp7b(-/-) kidney due to compensatory export of copper by ATP7A Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
Mus musculus ADP + phosphate + Cu2+/out
-
?
ATP + H2O + Cu2+/in age-dependent expression studies in kidney, role for ATP7A in renal response to changes in copper load Mus musculus ADP + phosphate + Cu2+/out
-
?
ATP + H2O + Cu2+/in role for ATP7B in regulation of renal copper shown Mus musculus ADP + phosphate + Cu2+/out
-
?

Synonyms

Synonyms Comment Organism
ATP7A
-
Mus musculus
ATP7B
-
Mus musculus