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Literature summary for 7.2.2.9 extracted from
- Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases (2006), Biochem. Biophys. Res. Commun., 348, 428-436.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glutaredoxin | is essential for ATPase function and catalysis either the reduction of intramolecular disulphide bonds or the deglutathionylation of the cysteine residues within the CxxC motifs to facilitate copper-binding for subsequent transport | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P35670 | - |
- |
| Homo sapiens | Q04656 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin fibroblast | overexpressing ATP7A or ATP7B | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cu2+/in | ATP7A and ATP7B are the key copper transporters that regulate copper homeostasis | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATP7A | - |
Homo sapiens |
| ATP7B | - |
Homo sapiens |
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