Literature summary for 7.2.2.9 extracted from

Ackland, M.L.; Anikijenko, P.; Michalczyk, A.; Mercer, J.F.B.
Expression of Menkes copper-transporting ATPase, MNK, in lactating human breast: possible role in copper transport into milk (1999), J. Histochem. Cytochem., 47, 1553-1561.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	in nonlactating breast epithelial cells the enzyme has a predominantly perinuclear distribution, in lactating breast tissue the enzyme appears as a granular, diffuse pattern that extends beyond the perinuclear region of the cell in both alveoli. Relocalization of the enzyme is a physiological process, which may be mediated by copper levels in the breast or by hormones and other events taking place during lactation	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Cu2+/in	Homo sapiens	relocalization of the enzyme is a physiological process, which may be mediated by copper levels in the breast or by hormones and other events taking place during lactation	ADP + phosphate + Cu2+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	expression is greater in lactating tissue than in nonlactating tissue, detected in luminal epithelial cells of the alveoli and ducts but not in myoepithelial cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu2+/in	-	Homo sapiens	ADP + phosphate + Cu2+/out	-	?
ATP + H2O + Cu2+/in	relocalization of the enzyme is a physiological process, which may be mediated by copper levels in the breast or by hormones and other events taking place during lactation	Homo sapiens	ADP + phosphate + Cu2+/out	-	?

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Release 2023.1 (January 2023)