Literature summary for 7.2.2.9 extracted from

Petris, M.J.; Mercer, J.F.B.; Culvenor, J.G.; Lockhart, P.; Gleeson, P.AS.; Camakaris, J.
Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking (1996), EMBO J., 15, 6084-6095.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	the enzyme is predominantly localized to the Golgi apparatus of cells, the enzyme continuously recycles between the Golgi and the plasma membrane, and elevated copper shifts the steady-state distribution from the Golgi to the plasma membrane	Cricetinae	5794	-
membrane	the enzyme continuously recycles between the Golgi and the plasma membrane, and elevated copper shifts the steady-state distribution from the Golgi to the plasma membrane	Cricetinae	16020	-

Organism

Organism	UniProt	Comment	Textmining
Cricetinae	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	copper-resistant CHO cells which overexpress the enzyme	Cricetinae	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu2+/in	-	Cricetinae	ADP + phosphate + Cu2+/out	-	?

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Release 2023.1 (January 2023)