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Literature summary for 7.2.2.8 extracted from

  • Rupp, J.; Locatelli, M.; Grieser, A.; Ramos, A.; Campbell, P.; Yi, H.; Steel, J.; Burkhead, J.; Bortz, E.
    Host cell copper transporters CTR1 and ATP7A are important for influenza A virus replication (2017), Virol. J., 14, 1-12 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.8

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04656
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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lung
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function RNAi knockdown of the high-affinity copper importer CTR1 results in significant viral growth defects of the influenza A virus (7.3fold reduced titer at 24 hours post-infection). Knockdown of CTR1 or the trans-Golgi copper transporter ATP7A significantly reduces polymerase activity in a minigenome assay. Both copper transporters are required for authentic viral RNA synthesis and nucleoprotein and matrix (M1) protein accumulation in the infected cell Homo sapiens