Literature summary for 7.2.2.8 extracted from

Acevedo, K.; Hayne, D.; McInnes, L.; Noor, A.; Duncan, C.; Moujalled, D.; Volitakis, I.; Rigopoulos, A.; Barnham, K.; Villemagne, V.; White, A.; Donnelly, P.
Effect of structural modifications to glyoxal-bis(thiosemicarbazonato)copper(II) complexes on cellular copper uptake, copper-mediated ATP7A trafficking, and P-glycoprotein mediated efflux (2018), J. Med. Chem., 61, 711-723 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
glyoxal-bis(N-4,4-pyrolidine-3-thiosemicarbazonato)copper(II)	treatment of SKOV-3 cells with micromolar concentrations leads to trafficking of the endogenous copper transporter ATP7A from the Golgi network to the cell membrane	Homo sapiens
glyoxal-bis(N-4-methyl-3-thiosemicarbazonato)copper(II)	treatment of SKOV-3 cells with micromolar concentrations leads to trafficking of the endogenous copper transporter ATP7A from the Golgi network to the cell membrane	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q04656	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)