Literature summary for 7.2.2.8 extracted from

Schwab, S.; Shearer, J.; Conklin, S.E.; Alies, B.; Haas, K.L.
Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2 (2016), J. Inorg. Biochem., 158, 70-76 .

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15431	-	-

Synonyms

Synonyms	Comment	Organism
Ctr1	-	Homo sapiens
SLC31A1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme specifically transports Cu(I) , but Ctr1 peptides bind Cu(II) at an amino terminal high-affinity Cu(II), Ni(II) (ATCUN) site. Ascorbate-dependent reduction of the Cu(II)-high-affinity Cu(II), Ni(II) (ATCUN) site is possible by virtue of an adjacent bis-His motif. Changes in the sequence proximity of the high-affinity site and bis-His motif lead to significant differences in coordination structure and chemical behavior	Homo sapiens

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Release 2023.1 (January 2023)