Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.8 extracted from

  • Zhu, S.; Shanbhag, V.; Wang, Y.; Lee, J.; Petris, M.
    A role for the ATP7A copper transporter in tumorigenesis and cisplatin resistance (2017), J. Cancer, 8, 1952-1958 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.8

Application

Application Comment Organism
medicine deletion of isoform ATP7A in H-RAS transformed tumorigenic mouse embryonic markedly suppresses tumorigenesis relative to wild type parental cells, associated with hyperaccumulation of copper and sensitivity to reactive oxygen species and hypoxia. Tumor grafts lacking ATP7A are markedly more sensitive to cisplatin chemotherapy compared to ATP7A-expressing control tumors Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function deletion of isoform ATP7A in H-RAS transformed tumorigenic mouse embryonic markedly suppresses tumorigenesis relative to wild type parental cells, associated with hyperaccumulation of copper and sensitivity to reactive oxygen species and hypoxia. Tumor grafts lacking ATP7A are markedly more sensitive to cisplatin chemotherapy compared to ATP7A-expressing control tumors Mus musculus