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Literature summary for 7.2.2.8 extracted from

  • Li, Z.H.; Zheng, R.; Chen, J.T.; Jia, J.; Qiu, M.
    The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC) (2016), J. Cancer, 7, 2085-2092 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine cisplatin-resistant cell sublines show cross-resistance to carboplatin and oxaliplatin. ATP7A expression in cisplatin-resistant cell sublines is much higher than in cisplatin-sensitive cell lines at both mRNA and protein levels. ATP7A-targeted siRNA in cisplatin-resistant cancer cells partially reverses cisplatin-resistance. It also increases cell apoptosis at different cisplatin concentrations Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
EC-109 cell
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Homo sapiens
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esophageal squamous cell carcinoma cell
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Homo sapiens
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