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Literature summary for 7.2.2.7 extracted from

  • Anderson, D.S.; Adhikari, P.; Weaver, K.D.; Crumbliss, A.L.; Mietzner, T.A.
    The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants (2007), J. Bacteriol., 189, 5130-5141.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
for expression in Escherichia coli cells Haemophilus influenzae

Protein Variants

Protein Variants Comment Organism
E149Q effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 95% Haemophilus influenzae
F162L effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 104% Haemophilus influenzae
G155A effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 76% Haemophilus influenzae
G155E effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 111% Haemophilus influenzae
G155V effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 88% Haemophilus influenzae
G418A effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 38% Haemophilus influenzae
I174F effect of permease mutaion on transport is measured, remaining transport rate 27% Haemophilus influenzae
I174N effect of permease mutaion on transport is measured, remaining transport rate 89% Haemophilus influenzae
I174N/S475I effect of permease mutaion on transport is measured, remaining transport rate 9% Haemophilus influenzae
I383N effect of permease mutaion on transport is measured, remaining transport rate 100% Haemophilus influenzae
I497V effect of permease mutaion on transport is measured, remaining transport rate 100% Haemophilus influenzae
L154D effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 35% Haemophilus influenzae
L417D effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 5% Haemophilus influenzae
P168A effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 116% Haemophilus influenzae
S146Y effect of permease mutaion on transport is measured, remaining transport rate 18% Haemophilus influenzae
S153A effect of motif 1 and 2 mutations on transport is measured, remaining transport rate 112% Haemophilus influenzae
S475I effect of permease mutaion on transport is measured, remaining transport rate 12% Haemophilus influenzae
V497I effect of permease mutaion on transport is measured, remaining transport rate 23% Haemophilus influenzae

Inhibitors

Inhibitors Comment Organism Structure
gallium
-
Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Fe3+/out Haemophilus influenzae shuttling of free Fe3+ through the periplasm ADP + phosphate + Fe3+/in
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Fe3+/out shuttling of free Fe3+ through the periplasm Haemophilus influenzae ADP + phosphate + Fe3+/in
-
?

Synonyms

Synonyms Comment Organism
Fe3+transporting ATPase
-
Haemophilus influenzae
hFbpABC transporter
-
Haemophilus influenzae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
radio-labeled iron transport assay Haemophilus influenzae