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Literature summary for 7.2.2.3 extracted from

  • Krauke, Y.; Sychrova, H.
    Cnh1 Na+ /H+ antiporter and Ena1 Na+-ATPase play different roles in cation homeostasis and cell physiology of Candida glabrata (2011), FEMS Yeast Res., 11, 29-41.
    View publication on PubMed
Search for more literature for 7.2.2.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain w303-1a [Candida] glabrata

Organism

Organism UniProt Comment Textmining
[Candida] glabrata P13587
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 [Candida] glabrata ADP + phosphate + Na+/out
-
 ?
additional information the enzyme has broad substrate specificity for alkali metal cations and is able to transport both sodium and potassium when expressed in Saccharomyces cerevisiae [Candida] glabrata ?
-
 ?

Synonyms

Synonyms Comment Organism
Ena1
-
 [Candida] glabrata
Na+-ATPase
-
 [Candida] glabrata

Expression

Organism Comment Expression
[Candida] glabrata the Ena1 Na+-ATPase gene is highly upregulated by an increased osmotic pressure or sodium concentration (25fold increase of expression during the first 60 min of exposure to 1000 mM NaCl and then expression partly drops (12fold higher expression after 90 min)) up

General Information

General Information Comment Organism
malfunction deletion of ENA1 has no effect on the tolerance to potassium and rubidium. Mutant cells are unable to grow on media containing higher concentrations of sodium and lithium cations [Candida] glabrata
physiological function Na+ATPase is involved in Candida glabrata tolerance to high concentrations of Na+ and Li+ [Candida] glabrata